Larry David tries to convince Jerry Seinfeld to do a Seinfeld reunion show, even though in the past Larry has called the idea "pathetic". His reason for this is that he hopes to give his aspiring actress ex wife Cheryl David a prominent role as George's ex wife (based on her) and use this as a means of getting back together.
Susie Greene has Lyme Disease and Larry figures this out for her, and in doing so "saves her life". When he gets into an argument with the head of NBC, he later finds him exhibiting the same symptoms as Susie and briefly considers letting him die. Instead, he tells him he might have Lyme Disease, and he decides to pick up the reunion show.